Human Cancer Genomes Harbor the Mutational Signature of Tobacco-Specific Nitrosamines NNN and NNK
New Study Identifies a Distinct Cancer-Causing Signature Left by Tobacco-Specific Chemicals in the Genome
Tobacco smoke contains two potent cancer-causing chemicals, NNN and NNK, which are known to damage DNA by forming what scientists call pyridyloxobutyl adducts. Until now, however, it was not well understood exactly what genetic "fingerprint," or mutational signature, this damage leaves behind in human cancers.